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. 2010 Feb 5;101(5):1226–1233. doi: 10.1111/j.1349-7006.2010.01523.x

Figure 5.

Figure 5

 Activation of mitogen‐activated protein kinase (MAPK) pathways by protein phosphatase 2A (PP2A) inhibitors. (a,b) Treatment of PANC‐1 cells with 10 μm cantharidin or 15 nm okadaic acid (OA) induced time‐dependent phosphorylation of ERK, JNK, and p38. Total protein level of ERK was also up‐regulated. The expressions of JNK and p38 did not show significant changes. (b,c) Time‐dependent growth inhibition of PANC‐1 cells triggered by PP2A inhibitors could be attenuated by SP600125 (JNK inhibitor), but not PD98059 (ERK pathway inhibitor) or SB203580 (p38 inhibitor). **P < 0.01 indicates significant differences from the cantharidin‐ or OA‐treated groups.