Table 2.
Expression of Met‐enkephalin (MENK) in 61 human human colorectal cancers
| Pathological parameters | Immunohistochemical grade ‡ | P‐value | ||
|---|---|---|---|---|
| 1 | 2 | 3 | ||
| Differentiation | ||||
| Well | 13 | 15 | 6 | |
| Mod | 15 | 7 | 5 | NS § |
| Pathological stage † | ||||
| B | 21 | 4 | 0 | |
| C | 7 | 11 | 3 | |
| D | 0 | 7 | 8 | <0.0001 |
| Nodal metastasis | ||||
| Negative | 21 | 4 | 5 | |
| Positive | 7 | 18 | 6 | 0.0003 |
| Liver metastasis | ||||
| Negative | 28 | 15 | 3 | |
| Positive | 0 | 7 | 8 | <0.0001 |
Well, well‐differentiated adenocarcinoma; Mod, moderately differentiated adenocarcinoma.
†
Dukes’ stage B, tumor invades beyond the muscularis propria without lymph node metastasis; Dukes’ stage C, any case with lymph node metastasis; Dukes’ stage D, any case with or without lymph node metastasis but with distant metastasis.
‡
We classified the immunoreactivity into four grades by Allred's score( 16 ): grade 0, Allred's score 0; grade 1, Allred's score between 1 and 4; grade 2, Allred's score between 5 and 6; grade 3, Allred's score between 7 and 8.
§
Statistical difference was calculated by a χ2‐test. NS, not significant.