Table 1.
Clinicopathological and molecular features of 21 endometrial cancers with mutations in the PTEN or PIK3CA genes
| Patient no. | Age (years) | FIGO stage | Grade | MSI | PTEN mutation | PIK3CA mutation | p‐AKT expression † |
|---|---|---|---|---|---|---|---|
| 1 | 70 | Ib | 1 | H | Ex5; G389T, R130L | Ex20; A3140T, H1047L | + |
| 2 | 58 | Ib | 3 | L | Ex20; A3140G, H1047R | − | |
| 3 | 71 | Ib | 1 | H | Ex8; G871A, E291K Ex8; 863 del A, fs (stop at 868) | Ex20; A3140T, H1047L | + |
| 4 | 52 | Ic | 2 | H | Ex8; 946 ins G, fs (stop at 970) Ex8; 987 del TAAA, fs (stop at 1024) | − | |
| 5 | 41 | Ic | 2 | H | Ex5; A446G, Q149R Ex8; 863 del A, fs (stop at 868) | ++ | |
| 6 | 44 | Ia | 1 | H | Ex8; A938G, K313R Ex8; 963 del A, fs (stop at 1027) | ++ | |
| 7 | 47 | Ib | 1 | H | Ex8; 963 del A, fs (stop at 1027) | ± | |
| 8 | 58 | Ib | 1 | H | Ex8; 923 ins A, fs (stop at 931) | − | |
| 9 | 62 | Ib | 2 | MSS | Ex20; A3140G, H1047R | − | |
| 10 | 54 | Ib | 1 | MSS | Ex5; C388G, R130G | + | |
| 11 | 64 | Ic | 2 | MSS | Ex1; A76C, T26P | − | |
| 12 | 43 | Ia | 1 | H | Ex8; A815G, H272R Ex8; 950 del TACT, fs (stop at 955) | + | |
| 13 | 67 | Ia | 1 | MSS | Ex5; G389A, R130Q | Ex9; C1636G, Q546E | ++ |
| 14 | 33 | Ia | 1 | H | Ex5; 336 del AAGTG, fs (stop at 340) | + | |
| 15 | 68 | Ia | 1 | H | Ex8; 956 del CTTT (stop at 1024) | + | |
| 16 | 49 | Ia | 1 | MSS | Ex5; C388T, R130stop | − | |
| 17 | 55 | Ic | 3 | L | Ex5; C462A, F154L | ++ | |
| 18 | 59 | Ib | 1 | H | Ex20; A3036G, E1002E | ++ | |
| 19 | 63 | Ib | 1 | MSS | Ex5; G389A, R130Q Ex5; C424T, R142W | Ex20; A3062G, Y1021C | ± |
| 20 | 55 | Ib | 1 | ND | Ex5; C388T, R130stop | ± | |
| 21 | 53 | Ic | 3 | ND | Ex5; 493 ins A, fs (stop at 499) | + |
†
– negative, +/– weak, + moderate, ++ strong. Some of the data have been reported previously.( 3 , 19 ) EX, exon; FIGO, International Federation of
Gynecology and Obstetrics; H, high‐frequency microsatellite instability; L, low‐frequency microsatellite instability; MSI, microsatellite instability; MSS, microsatellite stable; ND, not done; p‐AKT, phosphorylated AKT.