Table 3.
Genes of cluster 2
| Category | Gene name | GenBank accession number | Expression ratio | ||
|---|---|---|---|---|---|
| CON | NC | CA | |||
| Cell surface antigens | CD36 antigen‐like 2 | M68965 | 0.73 | 2.10 | 0.67 |
| Membrane channels/transporters | Inositol 1,4,5‐triphosphate receptor 3 | L06096 | 0.87 | 1.56 | 0.63 |
| X transporter protein 2 | U12973 | 0.87 | 1.67 | 0.45 | |
| ATPase, H+K+ transporting, non‐gastric, α polypeptide | M90398 | 0.69 | 1.65 | 0.55 | |
| Dopa decarboxylase | M27716 | 0.87 | 1.41 | 0.73 | |
| Synaptotagmin 2 | M64488 | 1.19 | 1.63 | 0.55 | |
| Fatty acid binding protein 2 | M35992 | 0.74 | 1.78 | 0.56 | |
| Interleukin‐2 receptor, β chain | M55050 | 1.15 | 1.44 | 0.55 | |
| Metabolism‐related factors | Cytochrome P450 1B1 | U09540 | 1.32 | 2.48 | 0.70 |
| Sucrose isomaltase | X15546 | 1.03 | 2.22 | 0.69 | |
| Propionyl coenzyme A carboxylase, β polypeptide | M14634 | 1.30 | 1.56 | 0.62 | |
| Mevalonate kinase | M29472 | 0.45 | 1.36 | 0.64 | |
| Hexokinase 2 | M68971 | 0.56 | 1.51 | 0.61 | |
| Plasma glutathione peroxidase precursor | D00680 | 1.34 | 1.19 | 0.52 | |
| Testis lipid binding protein | U07870 | 1.03 | 1.86 | 0.68 | |
| Lactate dehydrogenase 3, C chain | U07177 | 1.01 | 1.41 | 0.71 | |
| Solute carrier family 18, member 2 | M97381 | 0.56 | 1.71 | 0.68 | |
| Glycerol kinase | D16102 | 1.05 | 1.97 | 0.64 | |
| Cytochrome P450 3A9 | U60085 | 1.11 | 1.25 | 0.56 | |
| Apoptosis‐related factors | Caspase 3 | U49930 | 1.01 | 1.33 | 0.69 |
| α‐Inhibin | M36453 | 1.18 | 1.50 | 0.83 | |
| RNA processing/turnover/ transport‐related factors | Zinc finger protein 265 | AF013967 | 1.18 | 1.47 | 0.78 |
| Cell receptors | Opioid receptor, κ1 | D16829 | 0.82 | 1.55 | 0.78 |
| Neural receptor protein‐tyrosine kinase TrkB | M55291 | 0.51 | 1.42 | 0.67 | |
| Somatostatin receptor subtype 1 | X62314 | 1.01 | 2.15 | 0.58 | |
| Platelet‐derived growth factor receptor α | M63837 | 0.63 | 1.88 | 0.75 | |
| Diphtheria toxin receptor | L05489 | 0.79 | 1.84 | 0.67 | |
| Glutamate receptor, ionotropic, δ1 | U08255 | 0.95 | 1.72 | 0.72 | |
| Interleukin‐1 receptor‐like 1 | U04317 | 0.72 | 1.70 | 0.45 | |
| Endothelin receptor type A | X57764 | 0.60 | 1.53 | 0.50 | |
| Interleukin‐1 receptor, type I | M95578 | 0.80 | 1.47 | 0.56 | |
| Endothelin receptor type B | M60786 | 0.93 | 1.56 | 0.54 | |
| Cell signaling/extracellular communicatimg factors | β‐Nerve growth factor | M36589 | 0.54 | 1.72 | 0.81 |
| Cytokine‐induced neutrophil chemoattractant‐2 | D21095 | 1.29 | 1.45 | 0.46 | |
| Placental growth factor | L40030 | 0.96 | 1.90 | 0.42 | |
| Neurotrophin‐3 | M34643 | 1.23 | 1.36 | 0.74 | |
| Fibroblast growth factor‐5 | D64085 | 1.18 | 2.43 | 0.57 | |
| c‐fos induced growth factor | AF014827 | 0.97 | 1.82 | 0.66 | |
| Fibroblast growth factor‐9 | D14839 | 0.76 | 1.92 | 0.65 | |
| Intracellular transducers/ effectors/modulators | Annexin 1/p35/lipocortin 1 | M19967 | 1.04 | 1.37 | 0.61 |
| Insulin receptor substrate 1 | X58375 | 1.03 | 1.67 | 0.77 | |
| Neurofibromatosis type 1 | D45201 | 1.32 | 0.75 | 0.40 | |
| Phosphatidylinositol 4,5‐bisphosphate 5‐phosphatase, A | AB032551 | 0.84 | 1.48 | 0.47 | |
| Endothelin converting enzyme‐like 1 | AB026293 | 0.85 | 1.79 | 0.79 | |
| Src related tyrosine kinase | U09583 | 0.77 | 1.65 | 0.61 | |
| S6 kinase | M58340 | 0.99 | 1.79 | 0.51 | |
| Guanine nucleotide binding protein, γ7 | L23219 | 1.11 | 1.44 | 0.78 | |
| Polo‐like kinase homolog | U10188 | 1.02 | 1.40 | 0.47 | |
| Protein tyrosine phosphatase, non‐receptor type 5 | S49400 | 1.04 | 1.46 | 0.61 | |
| Cytoskeleton/motility proteins | Troponin 1, type 2 | M73701 | 0.56 | 1.89 | 0.77 |
| Others | P‐glycoprotein/multidrug resistance 1 | M81855 | 1.04 | 1.53 | 0.57 |
| Secretory zymogen granule membrane glycoprotein GP2 | M58716 | 1.05 | 1.53 | 0.56 | |
| Probasin | M27156 | 0.80 | 1.54 | 0.42 | |
| Palmitoyl‐protein thioesterase | L34262 | 0.51 | 2.30 | 0.62 | |
CON, normal liver; NC, surrounding non‐cancerous liver; CA, HCC sample.