Table 2.
Identification of epitopes recognized by five clones
| Clone | Minimal epitope † | Identified HLA‐restriction | Known epitope sequence | Reported HLA‐restriction | REF |
|---|---|---|---|---|---|
| X1‐12B12 | (F)EYHQEGGPDG(EP) | DR4 | |||
| X3‐11D1 | (SN)PKFENIAEGLR(A) | DP2, DP5 | NPKFENIAEGLRALL | DP, DR11 | 25 |
| X3‐3G2 | (RA)LLARSHVER(TTDE) | DQ6 | LRALLARSHVERTTD | ND | 25 |
| X4‐2C9 | (R)RGTALAIPQCRL(T) | DR51 | NLRRGTALAIPQCRL | DR4, DQ3 | 25 |
| W5‐9D5 | (FLQ)THIFAEVLKD(AIK) | DP5 | MVFLQTHIFAEVLKD | DR15 | 25 |
| VFLQTHIFAEVLKDLV | DP5 | 31 |
†
The minimal epitope represents the shortest fragment where any further truncation may result in drastic reduction of antigenicity. Addition of amino acids in parentheses may augment the antigenicity. HLA, human leukocyte antigen; ND, not determined; REF, reference.