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. 2006 Jun 9;97(8):753–759. doi: 10.1111/j.1349-7006.2006.00233.x

Figure 1.

Figure 1

A schematic representation of mutation analysis of the epidermal growth factor receptor (EGFR) gene. We previously reported 17 tumors with EGFR mutation detected by direct sequencing of exons 18, 19 and 21 among 85 non‐small cell lung carcinomas (NSCLC; as indicated in parentheses), and further carried out direct sequencing of exon 20. Direct sequencing analysis of a further 264 NSCLC revealed 93 tumors with EGFR mutation among a total of 349 NSCLC. As the L858R mutation was then detected by mutation‐specific polymerase chain reaction (PCR) in another nine tumors, we identified a total of 102 tumors with EGFR mutations (95 tumors with a single mutation and seven tumors with double mutations of EGFR).