Table 1.
Apparent dissociation constant (K d ) values of murine anti‐CD20 monoclonal antibodies (mAbs)
| Clone group | Clone( 30 ) | K d (nM) | Group |
|---|---|---|---|
| 2B8 | 3.88 ± 0.61 | B | |
| 2H7 | 1.30 ± 0.20 | A | |
| OUBM1 | 1k1402 | 0.77 ± 0.21 | A |
| OUBM2 | 1k1228 | 1.15 ± 0.10 | A |
| OUBM3 | 1k1782 | 1.20 ± 0.23 | A |
| OUBM4 | 1k1712 | 1.34 ± 0.16 | A |
| OUBM5 | 1k1736 | 1.46 ± 0.08 | A |
| OUBM6 | 1k1791 | 3.27 ± 0.72 | B |
| OUBM7 | 1k0924 | 3.69 ± 0.63 | B |
| OUBM8 | 1k1422 | 6.59 ± 0.36 | B |
Data represent mean values of three samples in separate two experiments, Anti‐CD20 mAbs in Group A have relatively high affinities with no apoptotic activities, while those in Group B have relatively low affinities and apoptotic activities. Anti‐CD20 mAbs in Group A can induce apoptosis only in the presence of secondary antibodies.