Table 2.
Summary of general data and incidences of gastric carcinomas in Mongolian gerbils
| Group | Treatment | Effective number | Body weight (g) | Total lignan intake (g) | Anti‐Hp IgG titer (AI) | Serum 8‐OHdG level (ng/mL) | Carcinoma† | ||
|---|---|---|---|---|---|---|---|---|---|
| Differentiated | Undifferentiated | Incidence (%) | |||||||
| A | Hp + MNU + 0.1% Arctigenin | 30 | 91.8 ± 14.0 | 0.942 ± 0.036 | 370.8 ± 35.6 | 0.448 ± 0.086** | 13 | 4 | 17/30 (56.7) |
| B | Hp + MNU + 0.25% NDGA | 33 | 79.0 ± 12.7* | 2.078 ± 0.054 | 306.0 ± 20.0 | 0.467 ± 0.123** | 11 | 2 | 13/33 (39.4)* |
| C | Hp + MNU + 0.05% NDGA | 29 | 90.5 ± 15.2 | 0.513 ± 0.056 | 280.9 ± 18.9 | 0.449 ± 0.064** | 15 | 1 | 16/29 (55.2) |
| D | Hp + MNU + 0.01% NDGA | 28 | 95.2 ± 14.2 | 0.108 ± 0.012 | 258.9 ± 38.9 | 0.583 ± 0.233 | 16 | 1 | 17/28 (60.7) |
| E | Hp + MNU | 29 | 92.0 ± 14.8 | 0 | 278.4 ± 25.5 | 0.590 ± 0.132*** | 17 | 2 | 19/29 (65.5) |
| F | Broth + 0.1% Arctigenin | 7 | 108.5 ± 10.6 | 1.094 ± 0.201 | 2.51 ± 0.81 | n.d. | 0 | 0 | 0/7 (0) |
| G | Broth + 0.25% NDGA | 8 | 94.8 ± 6.70*** | 2.573 ± 0.105 | 1.85 ± 0.19 | n.d. | 0 | 0 | 0/8 (0) |
| H | Broth | 14 | 106.6 ± 7.46 | 0 | 1.54 ± 0.29 | 0.485 ± 0.107 | 0 | 0 | 0/14 (0) |
†
Classification based on the histopathology. ‘Differentiated’ includes tubular types, whereas ‘undifferentiated’ consists of signet‐ring cell and poorly differentiated types.
*
P < 0.05 versus group E,
**
P < 0.01 versus group E,
***
P < 0.05 versus group H. Values for results are expressed as averages ± SD. 8‐OHdG, 8‐hydroxy‐2′‐deoxyguanosine; AI, arbitrary index; Hp, Helicobacter pylori; MNU, N‐methyl‐N‐nitrosourea; n.d., not determined; NDGA, nordihydroguaiaretic acid.