Table 4.
Up‐ and down‐regulated genes in 80 primary hepatocellular carcinomas with Aurora kinase B splicing variant 2 (AURKB‐Sv2) (+/–) (P < 0.0005, FC > 1.4). We used the expression data by Affymetrix HG‐U133 Plus 2.0 (54 675 probe sets)
| Gene symbol | Up‐regulated gene in AURKB‐Sv2(+) | |||
|---|---|---|---|---|
| Title | P‐value | FC | FDR | |
| 1559213_at | Homo sapiens, clone IMAGE:5394246, mRNA | 4.77E‐04 | 5.34 | 2.74E‐01 |
| SSX1 | synovial sarcoma, X breakpoint 1 | 3.83E‐04 | 4.51 | 2.74E‐01 |
| GPR88 | G protein‐coupled receptor 88 | 3.51E‐04 | 4.19 | 2.74E‐01 |
| COCH | coagulation factor C homolog, cochlin (Limulus polyphemus) | 7.33E‐05 | 3.47 | 2.16E‐01 |
| COCH | coagulation factor C homolog, cochlin (Limulus polyphemus) | 2.20E‐05 | 2.52 | 1.20E‐01 |
| MAGEA2///2B | melanoma antigen family A, 2///melanoma antigen family A, 2B | 1.59E‐04 | 2.32 | 2.35E‐01 |
| DSG2 | desmoglein 2 | 2.67E‐04 | 2.11 | 2.74E‐01 |
| LOC133874 | hypothetical gene LOC133874 | 9.88E‐05 | 1.92 | 2.16E‐01 |
| EPB41L2 | erythrocyte membrane protein band 4.1‐like 2 | 2.67E‐04 | 1.81 | 2.74E‐01 |
| TMEM48 | transmembrane protein 48 | 4.77E‐04 | 1.78 | 2.74E‐01 |
| CEACAM1 | carcinoembryonic antigen‐related cell adhesion molecule 1 (biliary glycoprotein) | 3.83E‐04 | 1.61 | 2.74E‐01 |
| PLXNC1 | plexin C1 | 3.67E‐04 | 1.59 | 2.74E‐01 |
| RAB3IP | RAB3A interacting protein (rabin3) | 2.93E‐04 | 1.59 | 2.74E‐01 |
| TMEM118 | transmembrane protein 118 | 1.26E‐04 | 1.55 | 2.30E‐01 |
| POT1 | POT1 protection of telomeres 1 homolog (S. pombe) | 3.51E‐04 | 1.53 | 2.74E‐01 |
| PSENEN | presenilin enhancer 2 homolog (C. elegans) | 1.58E‐05 | 1.52 | 1.20E‐01 |
| LOC642236 | similar to FRG1 protein (FSHD region gene 1 protein) | 5.21E‐04 | 1.52 | 2.74E‐01 |
| CKLF | chemokine‐like factor | 2.33E‐04 | 1.51 | 2.74E‐01 |
| MAPRE2 | microtubule‐associated protein, RP/EB family, member 2 | 2.03E‐04 | 1.49 | 2.52E‐01 |
| SSX3 | synovial sarcoma, X breakpoint 3 | 1.68E‐04 | 1.49 | 2.35E‐01 |
| CKLF | chemokine‐like factor | 1.94E‐04 | 1.46 | 2.46E‐01 |
| UROD | uroporphyrinogen decarboxylase | 1.26E‐04 | 1.44 | 2.30E‐01 |
| ULK4 | unc‐51‐like kinase 4 (C. elegans) | 2.93E‐04 | 1.42 | 2.74E‐01 |
| ERGIC3 | ERGIC and golgi 3 | 5.58E‐06 | 1.41 | 1.20E‐01 |
| ATP6V0B | ATPase, H + transporting, lysosomal 21 kDa, V0 subunit b | 1.68E‐04 | 1.41 | 2.35E‐01 |
| H3F3B | H3 histone, family 3B (H3.3B) | 4.19E‐04 | 1.40 | 2.74E‐01 |
| MED8 | mediator of RNA polymerase II transcription, subunit 8 homolog (S. cerevisiae) | 1.46E‐04 | 1.40 | 2.35E‐01 |
| AIP | aryl hydrocarbon receptor interacting protein | 1.46E‐04 | 1.40 | 2.35E‐01 |
| Gene symbol | Down‐Regulated Gene in AURKB‐Sv2(+) | |||
|---|---|---|---|---|
| Title | P‐value | FC | FDR | |
| 1562346_at | MRNA; cDNA DKFZp313F2234 (from clone DKFZp313F2234) | 3.21E‐04 | 0.89 | 2.74E‐01 |
| IL1RL1 | Interleukin 1 receptor‐like 1 | 4.01E‐04 | 0.89 | 2.74E‐01 |
| FUT6 | Fucosyltransferase 6 (alpha (1,3) fucosyltransferase) | 8.95E‐05 | 0.88 | 2.16E‐01 |
| IL28RA | interleukin 28 receptor, alpha (interferon, lambda receptor) | 3.06E‐04 | 0.88 | 2.74E‐01 |
| 1555488_at | NA | 5.21E‐04 | 0.88 | 2.74E‐01 |
| KCNAB3 | potassium voltage‐gated channel, shaker‐related subfamily, beta member 3 | 7.33E‐05 | 0.88 | 2.16E‐01 |
| DIXDC1 | DIX domain containing 1 | 1.41E‐05 | 0.87 | 1.20E‐01 |
| 1569912_at | Homo sapiens, clone IMAGE:5459012, mRNA | 1.74E‐06 | 0.87 | 9.52E‐02 |
| 236991_at | Transcribed locus | 1.20E‐04 | 0.87 | 2.30E‐01 |
| ZNF474 | zinc finger protein 474 | 9.33E‐05 | 0.87 | 2.16E‐01 |
| CCDC85A | Coiled‐coil domain containing 85A | 4.77E‐04 | 0.87 | 2.74E‐01 |
| BAI2 | brain‐specific angiogenesis inhibitor 2 | 2.55E‐04 | 0.87 | 2.74E‐01 |
| MDGA1 | MAM domain containing glycosylphosphatidylinositol anchor 1 | 1.46E‐04 | 0.87 | 2.35E‐01 |
| KIAA1787 | KIAA1787 protein | 5.44E‐04 | 0.86 | 2.74E‐01 |
| MORN1 | MORN repeat containing 1 | 4.99E‐04 | 0.86 | 2.74E‐01 |
| FAM41AY | family with sequence similarity 41, member A, Y‐linked | 8.04E‐05 | 0.86 | 2.16E‐01 |
| ITGA10 | integrin, alpha 10 | 5.99E‐05 | 0.85 | 2.16E‐01 |
| 236541_at | Transcribed locus | 4.99E‐04 | 0.84 | 2.74E‐01 |
| AMACR | alpha‐methylacyl‐CoA racemase | 1.21E‐04 | 0.84 | 2.30E‐01 |
| DYNLRB2 | dynein, light chain, roadblock‐type 2 | 4.57E‐04 | 0.84 | 2.74E‐01 |
| RBM25 | RNA binding motif protein 25 | 1.85E‐04 | 0.83 | 2.46E‐01 |
| 228525_at | Transcribed locus, strongly similar to XP_512572.1 similar to low density lipoprotein receptor‐related protein 3 [Pan troglodytes] | 5.21E‐04 | 0.81 | 2.74E‐01 |
| LOC338328 | high density lipoprotein‐binding protein | 3.83E‐04 | 0.79 | 2.74E‐01 |
| CYP46A1 | cytochrome P450, family 46, subfamily A, polypeptide 1 | 2.20E‐05 | 0.77 | 1.20E‐01 |
| RICS | Rho GTPase‐activating protein | 3.51E‐04 | 0.73 | 2.74E‐01 |
| EML1 | echinoderm microtubule associated protein like 1 | 5.44E‐04 | 0.73 | 2.74E‐01 |
| DGCR5 | DiGeorge syndrome critical region gene 5 (non‐coding) | 1.67E‐04 | 0.72 | 2.35E‐01 |