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. 2005 Apr 8;96(4):212–217. doi: 10.1111/j.1349-7006.2005.00039.x

Figure 4.

Figure 4

Degradation of lumican by membrane type matrix metalloproteinases‐1 (MT1‐MMP) abrogates suppression of tumorigenicity. (a) Control HT1080 (–) or cells stably transfected with lumican gene (Lum) were cultured with or without BB94, and the supernatants and cell lysates were examined for the expression of lumican and p21/Waf‐1, respectively. b, control HT1080 (–) or HT1080/Lum cells were plated into 0.3% agarose with or without BB94, and colonies were observed under microscopy 2‐weeks after incubation. Note that the accumulation level of lumican protein correlates with p21/Waf‐1 expression level and reversely with colony forming ability in agarose.