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Runt‐related transcription factor‐3 (RUNX3) expressed in (a) cribriform, (b) tubular, and (c) solid patterns of ACC. (d) Tumor nest with perineural and intraneural invasion showed RUNX3 immunostaining in adenoid cystic carcinoma (ACC) cells and nerve cells (arrow). (e) In gland‐invasion type, RUNX3 protein is immunopositive in the normal salivary gland, but immunonegative in invasive ACC cells (streptavidin‐peroxidase, SP; 400×).
