Table 1.
Days after LPS | Gefitinib | LPS | SP‐A | Macrophages (%) | Neutrophils (%) |
---|---|---|---|---|---|
0 | – | – | – | 93.3 ± 0.3 | 2.1 ± 0.3 |
0 | + | – | – | 89.0 ± 1.5 | 6.9 ± 1.1 |
3 | – | + | – | 34.1 ± 5.5 | 61.0 ± 6.3 |
3 | + | + | – | 21.6 ± 2.4 | 72.5 ± 3.3 |
3 | + | + | + | 43.0 ± 1.6 | 40.7 ± 1.8** |
6 | – | + | – | 77.3 ± 2.8 | 6.0 ± 0.3 |
6 | + | + | – | 81.1 ± 0.6 | 13.5 ± 1.1 |
6 | + | + | + | 84.6 ± 3.6 | 1.3 ± 0.5* |
P < 0.05 (compared with gefitinib+/LPS + mice);
P < 0.01 (compared with gefitinib+/LPS + mice). BAL, bronchoalveolar lavage; LPS, lipopolysaccharide; SP, surfactant protein.