Table 1.
Characteristics of p210BCR/ABL tg/– Bcl11b +/– leukemic mice
| Mouse no. | Age at disease (months) | PB parameters | Macroscopic tumor sites | TCRβ status | p210BCR/ABL expression | Bcl11b expression | Bcl11b status | ||
|---|---|---|---|---|---|---|---|---|---|
| WBC (× 103/µL) | Hb (g/dL) | Plt (× 104/µL) | |||||||
| 1 | 3.1 | 35.0 | 12.5 | 65.6 | Thy, Spl | G/R | + | + | G/T |
| 2 | 3.3 | 5.0 | 10.5 | 64.8 | Thy, Spl | G/loss | + | + | G/T |
| 3 | 4.0 † | ND | ND | ND | Thy | ND | ND | ND | ND |
| 4 | 5.3 | 2.3 | 7.1 | 44.2 | Thy | G/loss | + | + | G/T |
| 5 | 6.0 | 12.0 | 12.3 | 35.5 | Thy, PE | G/loss | + | – | T/loss |
| 6 | 6.1 | 6.6 | 13.9 | 53.5 | Thy | G/R | + | – | T/loss |
| 7 | 6.4 | 14.6 | 15.5 | 47.1 | Thy, Spl | G/R | + | + | G/T |
| 8 | 6.9 | 1.5 | 14.1 | 74.9 | Thy, PE | G/R | + | – | T/loss |
†
Found dead. G, germline; Hb, hemoglobin; ND, not done; PB, peripheral blood; PE, pleural effusion; Plt, platelet; R, rearranged; Spl, spleen; T, targeted; Thy, thymus; WBC, white blood cell.