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. 2009 May 4;100(8):1382–1388. doi: 10.1111/j.1349-7006.2009.01207.x

Figure 3.

Figure 3

A model for NADPH oxidase (Nox) 1‐mediated suppression of actin stress fiber formation and cell adhesion. Nox1‐generated reactive oxygen species inactivate low molecular weight tyrosine phosphatase (LMW‐PTP) by oxidizing cysteine thiols, resulting in accumulation of active p190RhoGAP possibly tyrosine‐phosphorylated by Src family proteins. This causes downregulation of Rho activity and thereby depresses ROCK–LIMK–coffilin signaling, leading to disruption of actin stress fiber and focal adhesion formation.