Table 4.

Characteristics of p53 mutations in esophageal squamous cell carcinoma

ID	Smoking	Drinking	Betel	P53 mutation
				Exon/codon	Nucleotide mutation	Base change	Amino acid change
1	+	+	–	5/128	CCT→CTT	C→T	Pro→Leu
2	+	+	+	5/131	AAC→AGT	AC→GT	Asn→Ser
3	+	–	+	5/131	AAC→AGC	A→G	Asn→Ser
4	+	+	+	5/131	AAC→AGC	A→G	Asn→Ser
5	–	+	+	5/131	AAC→AAG	C→G	Asn→Lys
				5/151	CCC→GCC	C→G	Pro→Ala
				8/275	TGT→TGC	T→C	Cys→Cys
6	+	–	+	5/133	ATG→AAG	T→A	Met→Lys
7	+	+	+	5/142	CCT→CCC	T→C	Pro→Pro
8	+	+	+	5/150	ACA→AAC	CA→AC	Thr→Asn
9	+	+	+	5/150	ACA→ACT	A→T	Thr→Thr
10	+	+	–	5/151	CCC→CAC	C→A	Pro→His
11	+	–	–	5/151	CCC→ACC	C→A	Pro→Thr
				5/153	CCC→GCC	C→G	Pro→Ala
12	+	–	–	5/154	GGC→GTC	G→T	Gly→Val
13	+	+	+	5/159	GCC→TCC	G→T	Ala→Ser
14	–	–	–	5/161	GCC→GGC	C→G	Ala→Gly
15	+	+	+	5/175	CGC→CAC	G→A	Arg→His
16	+	+	+	5/179	CAT→CTT	A→T	His→Leu
17	+	+	+	5/184	AGA→AAA	A→T	Arg→Lys
18	+	+	+	5/185	AGC→AGA	C→A	Ser→Arg
19	+	–	–	5/186	GAT→AAT	G→A	Asp→Asn
20	+	+	+	6/193	CAT→CGT	A→G	His→Arg
21	+	+	+	6/193	CAT→CCT	A→C	His→Pro
22	+	–	+	6/203	CAT→GAT	C→G	Asp→Asp
23	+	+	+	6/210	AAC→AGC	A→G	Asn→Ser
24	+	+	+	7/237	ATG→GTG	A→G	Met→Val
25	+	+	–	7/238	TGT→TTT	G→T	Cys→phe
26	+	+	+	7/239	AAC→GAC	A→G	Asn→Ser
27	+	+	+	7/241	TCC→TTC	C→T	Ser→Phe
28	+	+	–	7/242	TGC→TAC	G→A	Cys→Tyr
29	+	+	+	7/249	AGG→AGT	G→T	Arg→Ser
30	+	–	+	7/256	ACA→GCA	A→G	Thr→Ala
31	+	–	–	7/259	GAC→TAC	G→T	Asp→Tyr
32	+	–	–	8/266	GGA→GAA	G→A	Gly→Glu
33	–	+	+	8/273	CGT→CTT	G→T	Arg→Leu
34	+	+	–	8/294	GAG→GCG	A→C	Glu→Ala