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Dose reduction and discontinuance of thalidomide. Although 400 mg thalidomide daily was the standard dose for all patients, only a limited number of patients could tolerate this dose longer than 6 months because of the toxicities. (a) Time to cessation of thalidomide; (b) time to the first dose reduction; (c) time course change of the daily dose during thalidomide monotherapy. A daily dose of 200 mg or less is considered optimal for long‐term use.
