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Time course change of the frequency of the primary adverse events during thalidomide monotherapy. Somnolence, fever, and neutropenia emerged in the first 2 weeks, and their frequency declined over time. In contrast, the frequency of peripheral neuropathy, constipation, and dry mouth increased gradually with increasing duration of treatment, 
peripheral neuropathy; 
dry mouth; 
constipation; 
somnolence; 
fever; 
neutropenia.
