Table 3.
Pharmacokinetics of PF‐3512676
| Dose level | n | Mean C max, ng/mL (SD) | Mean AUC(0–∞), ng × h/mL (SD) | Median t max, hours (range) | Mean t 1/2, hours (SD) |
|---|---|---|---|---|---|
| Monotherapy | |||||
| 0.1 mg/kg | 3 | 90 (36) | 376 (73) | 2 (2–3) | 4.8 (3.4) |
| 0.2 mg/kg | 6 | 217 (90) | 856 (127) | 2 (1–3) | 12.8 (14.0) |
| 0.4 mg/kg | 3 | 1010 (633) | 5270 (2450) | 2 (2–2)† | 21.6 (16.4) |
| Combination therapy | |||||
| 0.1 mg/kg | 3 | 55 (19) | 379 (55) | 3 (2–3) | 7.9 (6.2) |
| 0.2 mg/kg | 9 | 226 (124) | 1340 (775) | 2 (1–3) | 9.5 (6.9) |
†All patients had reached maximum concentration of PF‐3512676 by 2 h postdose. AUC, area under the curve; C max, peak plasma concentration; SD, standard deviation; t ½, half‐life; t max, time to maximum plasma concentration.