Table 4.

 Results of multivariate analysis for recurrence after curative surgery in 96 colorectal cancers

Molecules	Recurrence*		Univariate		Multivariate
	+	−	t‐test	Logistic	Stepwise
			P‐value	P‐value	P‐value
IL‐6R	63	51	0.03	n.s.
MMP‐9	37	35	n.s.	n.s.
TIMP‐1	119	113	n.s.	n.s.
TIMP‐2	25	24	n.s.	n.s.
Endostatin	193	186	n.s.	n.s.
P‐selectin	76	60	0.04	n.s.
ICAM‐1	285	281	n.s.	n.s.
VCAM‐1	164	135	0.02	0.039	0.009
Tie‐2	183	127	n.s.	n.s.
PAI‐1	28.3	19.8	0.02	0.005	0.005
MIF	64	51	n.s.	n.s.
uPAR	30	21	n.s.	n.s.
Ang‐2	1514	1292	n.s.	n.s.
Follistatin	962	883	n.s.	n.s.
HGF	3155	2517	n.s.	n.s.
IL‐8	53	49	n.s.	n.s.
G‐CSF	892	810	n.s.	n.s.
PDGF‐BB	972	671	n.s.	n.s.
VEGF	211	174	n.s.	n.s.
Leptin	2623	3196	n.s.	n.s.
PECAM‐1	6159	5447	n.s.	n.s.
IL‐12	4	5	n.s.	n.s.
FGF‐basic	16	22	n.s.	n.s.
TNF‐α	4	4	n.s.	n.s.

*Values indicate the average. Recurrence, post‐operative recurrence; logistic, logistic regression model. The concentrations are ng/mL for interleukin 6 receptor (IL‐6R), matrix metallopeptidase 9 (MMP‐9), TIMP metallopeptidase inhibitor 1 (TIMP‐1), TIMP‐2, endostatin, P‐selectin, intercellular adhesion molecule 1 (ICAM‐1), vascular cell adhesion molecule 1 (VCAM‐1), Tie‐2, plasminogen activator inhibitor‐1 (PAI‐1), macrophage migration inhibitory factor (MIF), and plasminogen activator urokinase receptor (uPAR), and the others are pg/mL. FGF‐basic, fibroblast growth factor 2; G‐CSF, colony stimulating factor 3; HGF, hepatocyte growth factor; n.s., not significant; PDGF‐BB, platelet‐derived growth factor beta polypeptide; PECAM‐1, platelet/endothelial cell adhesion molecule; TNF‐α, tumor necrosis factor; VEGF, vascular endothelial growth factor.