Table 1.
Background of subjects enrolled in the study
| Variables | All | Non‐carrier | Deleterious mutations in | ||
|---|---|---|---|---|---|
| BRCA1/2 | BRCA1 | BRCA2 | |||
| Number of patients | 135 | 99 | 36 | 17 | 19 |
| Age at enrollment | 51.6 ± 12.4 | 52.5 ± 12.7* | 49.1 ± 11.3* | 48.9 ± 10.1 | 49.2 ± 12.5 |
| Number of sessions for genetic counseling | 3.36 ± 0.82 (1–8) ‡ | 3.22 ± 0.56 (1–5)*** | 3.75 ± 1.20 (1–8)*** | – | – |
| Sex | |||||
| Female | 131 | 96 | 35 | 17 | 18 |
| Male | 4 | 3 | 1 | 0 | 1 |
| Types of affected cancer | |||||
| Female | |||||
| Breast | 113 | 83 | 30 | 12 | 18 |
| Ovarian | 9 | 8 | 1 | 1 | 0 |
| Both | 9 | 5 | 4 | 4 | 0 |
| Male | |||||
| Breast | 4 | 3 | 1 | 0 | 1 |
| Genealogical information; number of relatives ascertained | |||||
| Relatives ≤ 1st degree | 673 (4.99) † | 487 (4.92)** | 186 (5.16)** | 92 (5.41) | 94 (4.95) |
| Male | 305 (2.26) | 218 (2.20) | 87 (2.42) | 42 (2.47) | 45 (2.37) |
| Female | 368 (2.73) | 269 (2.72) | 99 (2.75) | 50 (2.94) | 49 (2.58) |
| 1st < Relatives ≤ 2nd degree | 1142 (8.46) | 825 (8.33)** | 317 (8.80)** | 166 (9.76) | 151 (7.95) |
| Male | 526 (3.90) | 383 (3.87) | 143 (3.97) | 72 (4.24) | 71 (3.74) |
| Female | 616 (4.56) | 442 (4.46) | 174 (4.83) | 94 (5.53) | 80 (4.21) |
| Relatives > 2nd degree | 427 (3.16) | 254 (2.57)** | 173 (4.81)** | 106 (6.24) | 67 (3.53) |
| Male | 192 (1.42) | 112 (1.13) | 80 (2.22) | 55 (3.24) | 25 (1.32) |
| Female | 235 (1.74) | 142 (1.43) | 93 (2.58) | 51 (3.00) | 42 (2.21) |
†
Numbers in parentheses indicate average number of relatives in a family.
‡
‡Minimal and maximal.
***
P = 0.0007.
*
P = 0.1594, unpaired t‐test.
**
χ2 value 26.90, d.f. = 2, P < 0.0001.