Figure 3.
Correlation between adenomatous polyposis coli (APC) hypermethylation and protein expression. (a) APC protein expression did not correlate significantly with the occurrence of APC promoter methylation in atypical endometrial hyperplasia (P = 0.547). (b) No significant correlation was observed between APC immunoexpression and APC promoter hypermethylation in endometrial carcinoma (EC) stages I–IV (P = 0.506). The International Federation of Gynecology and Obstetrics (FIGO) staging system was applied. (c) APC protein expression correlated significantly with the occurrence of APC promoter methylation in FIGO stages I and II of EC (P = 0.039). (d) No significant correlation was observed between APC immunoexpression and APC promoter hypermethylation in advanced‐stage EC, FIGO III and IV (P = 0.101).