Table 2.
Adenomatous polyposis coli (APC) and epithelial cadherin (E‐cad) promoter methylation and Ki‐67 expression in relation to clinical and pathological variables of endometrial carcinoma patients
| Variables | No. of cases, n (86) | APC methylation Methylation, n (%) | E‐cad methylation Methylation, n (%) | Ki‐67 (IRS score) |
|---|---|---|---|---|
| FIGO stages | ||||
| I | 38 | 29 (76.3) | 9 (23.6) | 4.74 |
| II | 15 | 12 (80.0) | 4 (26.7) | 5.02 |
| III | 23 | 6 (26.1) | 4 (17.4) | 4.38 |
| IV | 10 | 2 (20.0) | 2 (20.0) | 4.99 |
| P < 0.0001 | NS | NS | ||
| Histological type | ||||
| Endometrioid | 71 | 42 (59.2) | 18 (25.4) | 4.52 |
| Non‐endometrioid | 15 | 7 (46.7) | 1 (6.7) | 4.86 |
| NS | NS | NS | ||
| Histological grading | ||||
| G1 | 25 | 11 (44.0) | 6 (24.0) | 4.60 |
| G2 | 43 | 24 (55.8) | 9 (20.9) | 4.93 |
| G3 | 18 | 14 (77.8) | 4 (22.2) | 6.94 |
| NS | NS | NS | ||
| Metastases | ||||
| PTs without M | 58 | 40 (68.9) | 13 (22.4) | 4.27 |
| PTs with M | 28 | 9 (32.1) | 6 (21.4) | 4.87 |
| P = 0.002 | NS | NS | ||
FIGO, International Federation of Gynecology and Obstetrics; IRS score, median value of immunohistochemical score of Ki‐67 expression; M, metastases; NS, not significant; PTs, primary tumors.