Table 2.
Summary of OR for XRCC3 Thr241Met polymorphism and lung cancer risk
| Subgroup | Number of comparisons | C/C vs T/T | (C/C+C/T) vs T/T | C/C vs (C/T+T/T) |
|---|---|---|---|---|
| Ethnicity | ||||
| Caucasian | 10 | 0.904 (0638–1.282)* | 0.886 (0.637–1.232)* | 1.031 (0.968–1.099) |
| Asian | 2 | 0.996 (0.983–1.010) | 0.997 (0.985–1.009) | 1.009 (0.960–1.060) |
| Design | ||||
| Hospital case‐control | 5 | 0.587 (0.291–1.181)* | 0.590 (0.313–1.112)* | 0.907 (0.676–1.218)* |
| Population case‐control | 8 | 1.018 (0.970–1.068) | 1.004 (0.977–1.031) | 1.071 (1.003–1.144)** |
| Smoking habits | ||||
| Never | 2 | NA | NA | 0.952 (0.851–1.065) |
| Heavy smokers | 4 | 0.975 (0.902–1.054) | 0.980 (0.938–1.024) | 0.835 (0.44–1.584) |
| Light smokers | 3 | NA | NA | 1.006 (0.854–1.186) |
| Overall | 12 | 0.888 (0.646–1.222)* | 0.871 (0.644–1.178)* | 1.016 (0.968–1.066) |
*Random effect estimate. **P = 0.041. OR, odds ratio; XRCC3, X‐ray repair cross‐complementing group 3.