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. 2008 Nov 19;99(12):2477–2484. doi: 10.1111/j.1349-7006.2008.00967.x

Figure 3.

Figure 3

Effector cells were CD4+ in both the orthotopic and liver metastasis models. One week after the final MUC1 DNA immunization, the mice were treated with anti‐CD4 (GK1.5) or CD8 (53–6.72) monoclonal antibody and injected with (a) SL4‐M11 or (b,c) SL4‐M8 as described in Figure 1. Vaccine effects were assessed by tumor growth in the (a) cecum, (b) spleen, and (c) liver. Open circles represent tumor‐free mice and filled circles represent tumor‐bearing mice. n.s., not significant; *P < 0.05; **P < 0.005.