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. 2008 Nov 19;99(12):2477–2484. doi: 10.1111/j.1349-7006.2008.00967.x

Figure 6.

Figure 6

The antitumor effector mechanism at the orthotopic sites was distinct from that in the liver metastasis. After MUC1 DNA immunization, the mice were treated with anti‐tumor necrosis factor (TNF)‐α (MP6‐XT22) or anti‐FasL (MFL4) monoclonal antibody and injected with MUC1‐transfected SL4 cells. Vaccine effects were assessed by tumor growth in the (a) cecum, (b) spleen, and (c) liver. Open circles represent tumor‐free mice and filled circles represent tumor‐bearing mice. n.s., not significant; *P < 0.05; **P < 0.005.