Table 1.
Clinical characteristics and outcome of 75 Philadelphia‐positive acute lymphoblastic leukemia patients according to Wnt methylation status
| Feature | Non‐methylated (n = 26) | Methylated (n = 49) | P‐value |
|---|---|---|---|
| Age (n) | 0.002 | ||
| <15 years | 9 | 3 | |
| ≥15 years | 17 | 46 | |
| <55 years | 11 | 27 | |
| ≥55 years | 6 | 19 | |
| Sex (male/female) (n) | 15/11 | 27/22 | Not significant |
| White blood cells (n) | Not significant | ||
| <50 × 109/L | 16 | 25 | |
| ≥50 × 109/L | 10 | 20 | |
| Cell phenotype (n) | Not significant | ||
| Pro‐B | 1 | 3 | |
| Pre‐B | 7 | 8 | |
| Common | 16 | 37 | |
| Biphenotypic | 2 | 1 | |
| Stem cell transplantation (n) | 9 | 15 | Not significant |
| Best response (n) | |||
| Complete remission | 23 | 34 | 0.04 |
| Relapse (n) | 10 | 34 | <0.001 |
| Death (n) | 14 | 48 | <0.001 |