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. 2009 Feb 24;100(4):698–708. doi: 10.1111/j.1349-7006.2009.01102.x

Figure 2.

Figure 2

Model of H19 and SNRPN imprint resetting in the human germline. Primordial germ cells (PGCs) before entering the genital ridge retain a somatic methylation pattern showing the paternal imprint at H19 differential methylated region (DMR) and the maternal imprint at SNRPN DMR (H19 DMR/SNRPN DMR is shown as MU/UM). When PGCs have entered the genital ridge, both homologs are unmethylated and the imprint is erased (UU/UU). Imprint is re‐established when both homologs of H19 DMR in male PGCs are methylated (MM) at premeiotic stage in the testis and both homologs of SNRPN DMR in female PGCs are methylated (MM) at meiosis in the ovary. M, methylated DMR; U, unmethylated DMR.