Table 2.
Incidence and multiplicity of hepatic neoplasms and foci of cellular alteration (FCA) in obese diabetic C57BL/KsJ‐db/db mice fed basal (CRF‐1), casein‐supplemented, or branched‐chain amino acid (BCAA)‐supplemented diets
| Group no. | Diet | No. of mice | Incidence (%) | Multiplicity (no. of neoplasms/mouse) (mean ± SD) | FCA (No./cm2) (mean ± SD) | |||
|---|---|---|---|---|---|---|---|---|
| Adenoma | HCC | Total | Adenoma | HCC | ||||
| 1 | CRF‐1 | 11 | 7/11 (64) | 1/11 (9) | 1.0 ± 1.1 | 0.9 ± 1.1 | 0.1 ± 0.3 | 14.4 ± 4.4 |
| 2 | Casein | 11 | 8/11 (73) | 3/11 (27) | 1.7 ± 1.3 | 1.5 ± 1.1 | 0.3 ± 0.5 | 19.1 ± 5.7 |
| 3 | BCAA | 11 | 2/11 (18)*,** | 0/11 (0) | 0.2 ± 0.4*,*** | 0.2 ± 0.4*** | 0 | 9.6 ± 5.1*,**** |
*P < 0.05, significantly different from Group 1; **P < 0.05, significantly different from Group 2; ***P < 0.01, significantly different from Group 2; ****P < 0.001, significantly different from Group 2. HCC, hepatocellular carcinoma.