Table 2.
Non‐hematological toxicities of high‐dose chemotherapy in 34 patients in the Japan Clinical Oncology Group study, JCOG 9208
| Toxicity | Grade 1 (%) | Grade 2 (%) | Grade 3 (%) | Grade 4 (%) | Any grade (%) |
|---|---|---|---|---|---|
| Nausea/vomiting | 3 (9) | 9 (26) | 22 (65) | 0 | 34 (100) |
| Diarrhea | 10 (29) | 11 (32) | 9 (26) | 1 (3) | 31 (91) |
| Mucositis | 16 (47) | 3 (9) | 5 (15) | 0 (0) | 24 (71) |
| Arrhythmia | 3 (9) | 1 (3) | 1 (3) | 0 (0) | 6 (18) |
| Infection | 9 (26) | 9 (26) | 2 (6) | 1 (3) | 20 (59) |
| Bilirubin | 0 | 4 (12) | 1 (3) | 0 (0) | 5 (15) |
| AST | 15 (44) | 12 (35) | 5 (15) | 0 (0) | 32 (94) |
| ALT | 10 (29) | 13 (38) | 7 (21) | 1 (3) | 31 (91) |
No therapy‐related death was observed during high‐dose chemotherapy. All toxicities were graded according to the toxicity grading criteria of JCOG,( 30 ) a modified and expanded version of the National Cancer Institute – Common Toxicity Criteria version 1.0. AST, aspartate aminotransferase; ALT, alanine aminotransferase.