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. 2009 Apr 15;100(7):1326–1334. doi: 10.1111/j.1349-7006.2009.01181.x

Figure 5.

Figure 5

The antibody titer against (a) Gene‐X and (b) thrombospondin (THBS)‐2 according to malignant pleural mesothelioma (MPM) patients, normal healthy persons, lung cancer patients with or without asbestos exposure, and breast cancer patients. To determine the clinical significance of these antigens, a comparison of antibody titers was carried out by ELISA. These data were analyzed with 1/100 dilutions of the sera, and the optical density at 450 nm is shown. The cut‐off values of Gene‐X and THBS‐2 were determined to be 0.414 and 0.079 respectively. (c) Postoperative time course of antibody titers against Gene‐X and THBS‐2 in patients M15 and M18. To determine the therapeutic effect before and after the operation, a comparison of antibody titers was carried out in patients M15 and M18 by ELISA. The optical densities at 450 nm were analyzed in the two patients. In both patients, the titers of antibodies against Gene‐X and THBS‐2 decreased from 2 to 4 months after surgical resection. The titers of antibody against THBS‐2 were increased at the time of recurrence.