Figure 1.

(a) Effect of simvastatin on cell morphology. Tu167 and JMAR cells were plated on 6‐well plates for 12 h and then treated with various concentrations of simvastatin for 48 h. Photographs were taken and representative fields are shown. (b) Effect of simvastatin on cytoskeletal structure of head and neck squamous cell carcinoma cells. Tu167 cells were seeded on fibronectin‐coated culture slides for 12 h and treated with or without 5 µM simvastatin for 24 h. Cells were then fixed and stained with phalloidin as described in the Materials and Methods section. Images were examined and photographed using confocal microscopy. Compared with control cells, simvastatin‐treated cells showed a dramatic disruption or fragmentation of actin stress fibers (→).