Table 1.
Up‐regulated genes after treatment with simvastatin in JMAR cells. Potential target genes were categorized according to their functions
| Function | Examples | Change (‐fold) |
|---|---|---|
| Signal transduction | calmodulin‐like 3 (CALML3) | 11.2 |
| connexin 26 (GJB2) | 4.6 | |
| phospholipase C, gamma 2 (PLCG2) | 4.3 | |
| regulator of G‐protein signaling 2 (RGS2) | 4.1 | |
| insulin‐like growth factor binding protein 6 (IGFBP6) | 4.1 | |
| Cell cycle | cyclin‐dependent kinase inhibitor 1C (p57) (CDKN1C) | 5.3 |
| cyclin‐dependent kinase inhibitor 1 A (p21) (CDKN1A) | 4.5 | |
| Apoptosis | BCL2 binding component 3 (BBC3) | 7.6 |
| BCL2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3) | 5.6 | |
| Transcriptional factor | Kruppel‐like factor 2 (KLF2) | 26.3 |
| activating transcription factor 3 (ATF3) | 6.1 | |
| Kruppel‐like factor 6 (KLF6) | 4.3 | |
| Metabolism | aldo‐keto reductase family 1, member C1 (AKR1C1) | 9.5 |
| aldehyde dehydrogenase 3 family, member A1 (ALDH3A1) | 7.1 | |
| Matrix metalloproteinase | matrix metalloproteinase 10 (MMP10) | 17.2 |
| matrix metalloproteinase 28 (MMP28) | 8.8 | |
| matrix metalloproteinase 1 (MMP1) | 7.9 | |
| matrix metalloproteinase 12 (MMP12) | 6.9 | |
| matrix metalloproteinase 13 (MMP13) | 6.1 | |
| Calcium binding protein | S100 calcium binding protein A8 (S100A8) | 17.3 |
| S100 calcium binding protein A6 (S100A6) | 6.9 | |
| S100 calcium binding protein A9 (S100A9) | 6.5 | |
| Extracellular matrix | spondin 2 (SPON2) | 8.6 |
| fibronectin type III domain containing 6 (MGC34923) | 5.0 | |
| collagen, type VII, alpha 1 (COL7A1) | 4.3 | |
| Cytokeratin | keratin 13 (KRT13) | 7.5 |
| keratin 15 (KRT15) | 7.0 | |
| keratin 17 (KRT17) | 4.3 |