Table 2.

Down‐regulated genes after treatment with simvastatin in JMAR cells. Potential target genes were categorized according to their functions

Function	Examples	Change (‐fold)
Signal transduction	lymphotoxin beta (LTB)	0.20
	AXL receptor tyrosine kinase (AXL)	0.22
	Rho GTPase activating protein 29 (PARG1)	0.23
	annexin A3 (ANXA3)	0.36
	Rac GTPase activating protein 1 (RACGAP1)	0.40
	serine/threonine kinase 6 (STK6)	0.40
Cell cycle	CDC cell division cycle 6 homolog (CDC6)	0.20
	MAD2 mitotic arrest deficient‐like 1 (MAD2L1)	0.22
	activator of S phase kinase (ASK)	0.25
	protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1)	0.25
	E2F transcription factor 1 (E2F1)	0.27
	cell division cycle 2, G1 to S and G2 to M (CDC2)	0.27
	proliferating cell nuclear antigen (PCNA)	0.29
	cyclin A2 (CCNA2)	0.31
	cyclin D1 (CCND1)	0.42
DNA replication	DNA replication factor (CDT1)	0.18
	CDC45 cell division cycle 45‐like (CDC45L)	0.20
	primase, polypeptide 1 (PRIM1)	0.22
	MCM4 minichromosome maintenance deficient 4 (MCM4)	0.23
	thymidylate synthase (TS)	0.24
	replication factor C (activator 1) 5 (RFC5)	0.25
Cell adhesion	catenin (cadherin‐associated protein), alpha‐like 1 (CTNNAL1)	0.17
	thrombospondin 1 (THBS1)	0.19
	cysteine‐rich, angiogenic inducer, 61 (CYR61)	0.25
	integrin, beta‐like 1 (ITGBL1)	0.35
	integrin beta 3 binding protein (ITGB3 BP)	0.39