Figure 4.

Representative DNA sequences of bisulfite‐treated DNA from ovarian cancer cell lines. CpG sites are underlined. Genomic DNA was modified with sodium bisulfite. This treatment resulted in the conversion of unmethylated cytosines to thymines, whereas the methylated cytosines remained unchanged. The degree of methylation at each CpG site was expressed as the peak height of the methylated cytosine relative to the peak height of total cytosine. No methylation of the promoter 0N region was present in the Caov‐3 cell line and partial methylation was present in the SKOV‐3 cell line.