Table 1.
Profiles of patients and controls (eight healthy donors: five men and three women, 12–40 years [mean ± SD, 27.7 ± 7.9])
| Case | Age (years) | Sex | Onset age of HMB (years) | Diagnosis | EBV‐TR Southern blot |
|---|---|---|---|---|---|
| 1 | 16 | F | 2 | HEN disease | Monoconal (PBMC) |
| 2 | 9 | F | 4 | HEN disease | Monoclonal (PBMC) |
| 3 | 16 | M | 3 | HEN disease | Monoclonal (PBMC, skin) |
| 4 | 2 | F | 1 | Borderline HEN † | Oligoclonal (PBMC) |
| 5 | 14 | F | 3 | Borderline HEN ‡ | Monoclonal (PBMC) |
| 6 | 22 | F | 18 | Borderline HEN § | Monoclonal (PBMC, skin) |
| 7 | 2 | M | No HMB | Simple responder | ND |
| 8 | 10 | M | No HMB | Simple responder, SLE | ND |
| 9 | 3 | F | No HMB | Simple responder | ND |
| 10 | 30 | F | No HMB | Simple responder | ND |
| 11 | 36 | F | No HMB | Simple responder | ND |
The antibody titers to EBV in cases 1–6 ranged as follows: VCA‐IgG, 160–5120; VCA‐IgM, <10 to 10; EADR, <10; and EBNA, <10 to 20. The reasons for the diagnosis of ‘borderline HEN disease’ are as follows: †Although the patient had HMB, the Southern blotting of EBV‐TR showed four oligoclonal band, and NK cell lymphocytosis was absent. ‡The patient had a monoclonal EBV‐TR band and NK cell lymphocytosis, but HMB and hydroa vacciniforme subsided spontaneously 4 years previously. §The patient had HMB and cutaneous vasculitis with a monoclonal EBV‐TR band both in PBMC and lesional skin, but the onset age of HMB was relatively high, and NK cell lymphocytosis was absent. ND, not done; SLE, systemic lupus erythematosus.