Table 2.

p53 mutations in lung adenocarcinomas and squamous cell carcinomas

Sequential no.	DNA no.	Age (years)	Sex	Smoking index †	Tumor		Exon	Mutation					Amino acid	Mutation pattern
								Codon		Base change by strand		Next letter of the mutation to 3′ on the transcribed strand
					Histology	pStage		No.	Letters	Non‐transcribed	Transcribed
1	198	55	M	700	Ad	IA	4	46	Repeat of 16 bp			−	Frameshift	Insertion
2	393	54	F	0	Ad	IIIB	4	98	Deletion of 1bp			−	Frameshift	Deletion
3	360	64	M	1760	Ad	IIB	4	104	CAG→CAT	G→T		−	Gln→His	TV
4	360	64	M	1760	Ad	IIB	4	105	GGC→TGC	G→T		−	Gly→Cys	TV
5	269	66	M	920	Ad	IIIB	4	110	Deletion of 1bp	CGT→GT		−	Frameshift	Deletion
6	138	44	M	0	Ad	IIIA	4	120	AAG→AGG	A→G		−	Lys→Arg	TS
7	316	60	M	0	Ad	IA	4	124	Insertion of 1bp			−	Frameshift	Insertion
8	136	50	M	1600	Ad	IB	4	125	ACG→ACT	G→T		−	Thr→Thr	TV
9	363	63	M	540	Ad	IIIB	4	125	ACG→ACA	G→A (CpG)		−	Thr→Thr	TS
10	111	54	M	540	Ad	IB	4	3′ junction	Deletion of 1bp	CGgt→CG_t		−	Splicing	Deletion
11	368	73	F	0	Ad	IIIB	4	41–53	Deletion of 38bp			−	Frameshift	Deletion
12	17	69	M	846	Ad	IA	4	113–119	Deletion of 19bp			−	Frameshift	Deletion
13	90	73	M	1040	Ad	IB	4	124	Deletion of 25bp			−	Frameshift	Deletion
14	203	67	F	0	Ad	IIIB	5	132	AAG→AGG	A→G		−	Lys→Arg	TS
15	307	66	M	740	Ad	IIIA	5	132	AAG→GAG	A→G		−	Lys→Gln	TS
16	105	61	M	1600	Ad	IB	5	135	TGC→TTC	G→T		−	Cys→Phe	TV
17	255	66	F	0	Ad	IIIB	5	136	CAA→TAA	C→T	G→A (non‐CpG)	−	Gln→Stop	TS
18	11	72	F	0	Ad	IIIB	5	138	GCC→GTC	C→T	G→A (non‐CpG)	−	Ala→Val	TS
19	19	57	F	0	Ad	IIIA	5	138	GCC→CCC	G→C		−	Ala→Pro	TV
20	208	71	M	990	Ad	IIIA	5	157	GTC→TTC	G→T		−	Val→Phe	TV
21	290	69	M	2820	Ad	IIIB	5	157	GTC→GGC	T→G	A→C	−	Val→Gly	TV
22	22	72	M	800	Ad	IIIA	5	158	CGC→CAC	G→A (CpG)		−	Arg→His	TS
23	96	60	M	800	Ad	IIA	5	158	CGC→CAC	G→A (CpG)		−	Arg→His	TS
24	173	54	M	680	Ad	IA	5	158	CGC→CTC	G→T		−	Arg→Leu	TV
25	197	47	M	1620	Ad	IIIA	5	158	CGC→CCC	G→C		−	Arg→Pro	TV
26	389	57	F	0	Ad	IIA	5	158	CGC→CAC	G→A (CpG)		−	Arg→His	TS
27	79	56	M	720	Ad	IIIB	5	159	Deletion of 2bp	GCC→C		−	Frameshift	Deletion
28	364	70	M	800	Ad	IB	5	159	GCC→GTC	C→T	G→A (non‐CpG)	−	Ala→Val	TS
29	315	81	M	0	Ad	IIIB	5	164	AAG→TAG	A→T		−	Lys→Stop	TV
30	293	60	M	1200	Ad	5	167	Deletion of 2bp	CAG→ G	−			Frameshift	Deletion
31	238	71	M	765	Ad	IIIB	5	171	GAG→TAG	G→T		−	Glu→Stop	TV
32	278	51	F	0	Ad	IV	5	172	Deletion of 2bp	GTT→T		−	Frameshift	Deletion
33	103	74	M	860	Ad	IA	5	175	CGC→CAC	G→A (CpG)		−	Arg→His	TS
34	134	26	F	0	Ad	IIIA	5	176	TGC→TTC	G→T		−	Cys→Phe	TV
35	399	51	F	420	Ad	IB	5	176	TGC→AGC	T→A	A→T	−	Cys→Ser	TV
36	142	70	M	561	Ad	IB	5	181	CGC→CCC	G→C		−	Arg→Pro	TV
37	352	64	F	0	Ad	IIIB	5	169–170	Insertion of 6bp			−	Inframe	Insertion
38	191	50	M	1160	Ad	IA	5	179–185	Deletion of 18bp			−	Inframe	Deletion
39	398	59	F	0	Ad	IIA	6	188	Duplication			−	Frameshift	Duplication
40	302	51	M	620	Ad	IB	6	189	GCC→GTC	C→T	G→A (non‐CpG)	−	Ala→Val	TS
41	160	50	M	2310	Ad	IIIB	6	190	Deletion of 1bp	CCT→CT	−		Frameshift	Deletion
42	380	38	F	0	Ad	IIA	6	194	CTT→CCT	T→C	A→G	−	Leu→Pro	TS
43	391	81	F	0	Ad	IV	6	196	CGA→TGA	C→T	G→A (CpG)	−	Arg→Stop	TS
44	97	54	M	960	Ad	IIIA	6	198	GAA→TAA	G→T		−	Glu→Stop	TV
45	361	69	M	920	Ad	IIIA	6	205	TAT→TGT	A→G		−	Tyr→Cys	TS
46	122	74	F	240	Ad	IIIA	6	209	AGA→TGA	A→T		−	Arg→Stop	TV
47	205	49	F	0	Ad	IB	6	213	CGA→TGA	C→T	G→A (CpG)	A	Arg→Stop	TS
48	329	53	M	100	Ad	IIA	6	215	AGT→ATT	G→T		−	Ser→lle	TV
49	357	68	F	0	Ad	IIIA	6	218	Deletion of 1bp	−			Frameshift	Deletion
50	350	63	F	0	Ad	IIIA	6	219	CCC→TCC	C→T	G→A (non‐CpG)	−	Pro→Ser	TS
51	77	41	F	0	Ad	IA	6	220	TAT→TGT	A→G	−		Tyr→Cys	TS
52	186	74	M	1060	Ad	IB	6	3′ junction	AGgt→AGat	G→A (non‐CpG)		−	Splicing	TS
53	89	41	M	750	Ad	IB	6	5′ junction	agG→atG	G→T		−	Splicing	TV
54	23	58	M	25	Ad	IA	7	234	TAC→TGC	A→G		−	Tyr→Cys	TS
55	38	77	F	0	Ad	IIIB	7	237	ATG→ATT	G→T		−	Met→lle	TV
56	86	56	M	900	Ad	IIIA	7	238	TGT→AGT	T→A	A→T	−	Cys→Ser	TV
57	157	49	M	20	Ad	IIA	7	238	TGT→AGT	T→A	A→T	−	Cys→Ser	TV
58	344	46	F	230	Ad	IIIB	7	239	AAC→GAC	A→G		−	Asn→Asp	TS
59	80	65	F	0	Ad	IA	7	241	Deletion of 1bp	TCC→TC		−	Frameshift	Deletion
60	101	68	F	75	Ad	IIIA	7	242	TGC→TAC	G→A (non‐CpG)		−	Cys→Tyr	TS
61	294	58	M	1440	Ad	IA	7	244	GGC→TGC	G→T		−	Gly→Cys	TV
62	28	47	M	650	Ad	IIIA	7	245	GGC→TGC	G→T		−	Gly→Cys	TV
63	66	51	F	0	Ad	IIIB	7	245	GGC→AGC	G→A (CpG)		−	Gly→Ser	TS
64	235	61	F	300	Ad	IIIB	7	245	GGC→CGC	G→C		−	Gly→Arg	TV
65	313	61	M	2420	Ad	IB	7	245	GGC→TGC	G→T		−	Gly→Cys	TV
66	381	61	M	1600	Ad	IIIB	7	245	GGC→GTC	G→T		−	Gly→Val	TV
67	33	37	F	30	Ad	IA	7	248	CGG→TGG	C→T	G→A (CpG)	G	Arg→Trp	TS
68	139	70	F	0	Ad	IA	7	248	CGG→CAG	G→A (CpG)		−	Arg→Gln	TS
69	297	59	M	570	Ad	IA	7	248	CGG→CAG	G→A (CpG)		−	Arg→Gln	TS
70	327	64	M	1020	Ad	IB	7	249	AGG→ATG	G→T		−	Arg→Met	TV
71	350	63	F	0	Ad	IIIA	7	258	GAA→GAC	A→C		−	Glu→Asp	TV
72	3	73	M	700	Ad	IIIB	7	259	GAC→AAC	G→A (non‐CpG)		−	Asp→Asn	TS
73	244	62	M	1000	Ad	IIIA	7	259	GAC→TAC	G→T		−	Asp→Tyr	TV
74	282	66	M	1290	Ad	IV	7	253‐254	Deletion of 3bp			−	Inframe	Deletion
75	49	49	F	0	Ad	IIIA	8	273	CGT→CAT	G→A (CpG)		−	Arg→His	TS
76	50	70	M	540	Ad	IIIA	8	273	CGT→CAT	G→A (CpG)		−	Arg→His	TS
77	69	58	M	1600	Ad	IIIA	8	273	CGT→TGT	C→T	G→A (CpG)	C	Arg→Cys	TS
78	100	48	M	900	Ad	IA	8	273	CGT→CTT	G→T		−	Arg→Leu	TV
79	152	68	F	0	Ad	IA	8	273	CGT→CTT	G→T		−	Arg→Leu	TV
80	174	72	M	510	Ad	IA	8	273	CGT→CAT	G→A (CpG)		−	Arg→His	TS
81	182	56	M	750	Ad	IA	8	273	CGT→TGT	C→T	G→A (CpG)	C	Arg→Cys	TS
82	215	63	M	0	Ad	IA	8	273	CGT→CTT	G→T		−	Arg→Leu	TV
83	259	56	M	435	Ad	IIIB	8	273	CGT→TGT	C→T	G→A (CpG)	C	Arg→Cys	TS
84	362	53	M	660	Ad	IIIB	8	273	CGT→TGT	C→T	G→A (CpG)	C	Arg→Cys	TS
85	34	59	M	480	Ad	IA	8	274	GTT→TTT	G→T		−	Val→Phe	TV
86	156	65	M	0	Ad	IA	8	275	TGT→TAT	G→A (non‐CpG)		−	Cys→Tyr	TS
87	244	62	M	1000	Ad	IIIA	8	281	GAC→TAC	G→T		−	Asp→Tyr	TV
88	155	63	F	0	Ad	IIIA	8	282	CGG→TGG	C→T	G→A (CpG)	G	Arg→Trp	TS
89	382	54	F	0	Ad	IB	8	282	CGG→TGG	C→T	G→A (CpG)	G	Arg→Trp	TS
90	400	61	M	820	Ad	IB	8	286	GAA→GTA	A→T		−	Glu→Val	TV
91	347	80	F	240	Ad	IIIA	8	287	GAG→TAG	G→T		−	Glu→Stop	TV
92	331	63	M	840	Ad	IA	8	298	GAG→TAG	G→T		−	Glu→Stop	TV
93	154	72	M	2520	Ad	IIIB	8	274	Deletion of 2bp	GTT→T		−	Frameshift	Deletion
94	17	69	M	846	Ad	IA	8	301	Deletion of 1bp	CCA→C A		−	Frameshift	Deletion
95	284	75	M	2120	Ad	IIIA	8	–262	Deletion of 17bp			−	Splicing	Deletion
96	15	64	M	660	Ad	IA	8	3′ junction	AGgt→AGtt	G→T		−	Splicing	TV
97	185	67	M	612	Ad	IIB	8	305–306	Repeat of 23bp			−	Frameshift	Insertion
98	83	65	F	0	Ad	IA	10	335	CGT→CAT	G→A (CpG)		−	Arg→His	TS
99	388	79	F	0	Ad	IIIB	10	342	CGA→TGA	C→T	G→A (CpG)	G	Arg→Stop	TS
100	148	51	F	0	Ad	IIIA	10	341	Deletion of 1bp	TTC→T C		−	Frameshift	Deletion
101	25	71	M	1020	Sq	IIIB	4	88	GCC→ACC	G→A (non CpG)		−	Ala→Thr	TS
102	24	71	M	1020	Sq	IIIB	4	103	TAC→TAG	C→G	G→C	−	Tyr→stop	TV
103	36	69	M	1020	Sq	IIB	5	130	CTC→GTC	C→G	G→C	−	Leu→Val	TV
104	16	76	M	1250	Sq	IIB	5	144	CAG→CCG	A→C	−	−	Gln→Pro	TV
105	43	76	M	780	Sq	IIIB	5	152	Deletion of 2bp	CCG→G	−	−	Frameshift	Deletion
106	33	75	M	1060	Sq	IB	5	154	GGC→GTC	G→T	−	−	Gly→Val	TV
107	44	79	M	0	Sq		5	157	GTC→TTC	G→T	−	−	Val→Phe	TV
108	30	71	M	2550	Sq	IB	5	163	TAC→TGC	A→G	−	−	Try→Cys	TS
109	21	69	M	2040	Sq	IA	5	166	TCA→TAA	C→A	G→T	−	Ser→stop	TV
110	9	59	M	1200	Sq	IIIA	5	175	CGC→CAC	G→A (CpG)	−	−	Arg→His	TS
111	28	60	M	1600	Sq	IIIB	5	175	CGC→CAC	G→A (CpG)	−	−	Arg→His	TS
112	27	67	M	470	Sq	IA	5	176	TGC→TAC	G→A (non CpG)	−	−	Cys→Tyr	TS
113	7	70	M	1250	Sq	IIIB	5	149‐175	Deletion of 79bp		−	−	Frameshift	Deletion
114	37	71	M	820	Sq	IB	5	5'junction	agTA→tgTA	a→t	−	−	splicing	TV
115	14	63	M	1505	Sq	IIIA	6	190	Deletion of 1bp	CCT→CT	−	−	Frameshift	Deletion
116	45	66	M	0	Sq	6	190	CCT→CTT	C→T	G→A (nonCpG)		−	Pro→Leu	TS
117	26	81	M	1100	Sq	IB	6	193	CAT→TAT	C→T	G→A (nonCpG)	−	His→Tyr	TS
118	19	70	M	1590	Sq	IIIA	6	195	ATC→ACC	T→C	A→G	−	lle→Thr	TS
119	42	69	M	960	Sq	IIIA	6	195	ATC→ACC	T→C	A→G	−	Ile→Thr	TS
120	15	49	M	300	Sq	IIIA	6	196	CGA→CCA	G→C	−	−	Arg→Pro	TV
121	35	65	M	1260	Sq	IIB	6	196	CGA→TGA	C→T	G→A (CpG)	G	Arg→stop	TS
122	2	71	M	0	Sq	IA	6	220	TAT→TGT	A→G	−	−	Try→Cys	TS
123	18	82	M	1170	Sq	IIIB	6	220	TAT→TGT	A→G	−	−	Try→Cys	TS
124	31	62	M	1320	Sq	IIB	6	220	TAT→TTT	A→T	−	−	Try→Cys	TV
125	38	61	M	1200	Sq	IB	6	220	TAT→TGT	A→G	−	−	Tyr→Cys	TS
126	41	66	M	966	Sq	IIIA	6	220	TAT→TGT	A→G	−	−	Tyr→Cys	TS
127	31	62	M	1320	Sq	IIB	6	221	Deletion of 1bp	GAG→AG	−	−	Frameshift	Deletion
128	40	69	M	490	Sq	IIIB	7	234	TAC→TGC	A→G	−	−	stop→Tro	TS
129	6	64	M	0	Sq	IIIA	7	236	TAC→TGC	A→G	−	−	Try→Cys	TS
130	11	65	M	760	Sq	IB	7	244	GGC→TGC	G→T	−	−	Gly→Cys	TV
131	3	70	F	1000	Sq	IIIB	7	245	GGC→TGC	G→T	−	−	Gly→Cys	TV
132	5	79	M	2205	Sq	IB	7	245	GGC→CGC	G→C	−	−	Gly→Arg	TV
133	10	66	M	709	Sq	IIIA	7	245	GGC→CGC	G→C	−	−	Gly→Arg	TV
134	23	68	M	1440	Sq	IIIA	7	245	GGC→GTC	G→T	−	−	Gly→Val	TV
135	29	43	M	440	Sq	IIIB	7	248	CGG→CTG	G→T	−	−	Arg→Leu	TV
136	43	76	M	780	Sq	IIIB	7	248	CGG→TGG	C→T	G→A (CpG)	G	Arg→Trp	TS
137	46	81	M	1200	Sq	IIB	7	248	CGG→CTG	G→T	−	−	Arg→Leu	TV
138	12	72	M	705	Sq	IA	7	249	AGG→ATG	G→T	−	−	Arg→Met	TV
139	25	71	M	1020	Sq	IIIB	7	249	AGG→AGT	G→T	−	Arg→Ser	TV
140	34	74	M	2750	Sq	IIA	8	266	GGA→TGA	G→T	−	−	Gly→stop	TV
141	22	53	M	1320	Sq	IIB	8	271	GAG→TAG	G→T	−	−	Glu→stop	TV
142	39	65	M	760	Sq	IIIB	8	272	GTG→TTG	G→T	−	−	Val→Leu	TV
143	13	68	M	1950	Sq	IIIA	8	273	CGT→TGT	C→T	G→A (CpG)	C	Arg→Cys	TS
144	32	65	F	400	Sq	IIB	8	280	AGA→GGA	A→G	−	−	Arg→Gly	TS
145	8	59	M	1260	Sq	IIIB	8	282	CGG→TGG	C→T	G→A (CpG)	G	Arg→Trp	TS
146	20	75	F	0	Sq	IIB	8	282	CGG→TGG	C→T	G→A (CpG)	G	Arg→Trp	TS
147	1	61	M	0	Sq	IIIB	10	337	CGC→CTC	G→T	−	−	Arg→Leu	TV
148	4	76	M	600	Sq	IB	10	342	CGA→TGA	C→T	G→A (CpG)	G	Arg→stop	TS
149	17	51	M	1240	Sq	IIA	10	5′ junction	agAT→tgAT	a→t	−	−	Splicing	TV

^† Smoking index is the number of cigarettes/day × years. TS, transition; TV, transversion.