Figure 9.

 Tumor formation in NOD/scid/γc^null (NOG) mice by epithelial cell adhesion molecule (EpCAM)⁺ and EpCAM⁻ clones with genetic modifications. (A,B) Effect of introduced EpCAM cDNA on tumor‐forming ability. The NOG mice were inoculated with EpCAM⁺ (A) or EpCAM⁻ clones (B) transfected with EpCAM cDNA or the control vector. The average tumor size from four mice is shown with SEM. (C) Effect of EpCAM knockdown in EpCAM⁺ cell clones on their tumor‐forming ability. The indicated number of EpCAM⁺ clones transfected with shRNA construct or the control were transplanted into NOG mice. The average tumor size from eight mice is shown with SEM. * represents P < 0.05.