Table 5.

Stratification analyses between the combined genotypes of the RUNX3 tSNPs (SNP3, SNP7, and SNP8) and gastric cancer risk

Variables	n (case/control)	Combined genotypes (case/control)				Crude OR (95% CI)	Adjusted OR (95% CI) †
		1–3 risk alleles		4–6 risk alleles
		n	%	n	%
Total	311/324	197/251	63.3/77.5	114/73	36.7/22.5	1.99 (1.41–2.82)	2.00 (1.41–2.85)
Age (years)
<65	178/183	118/132	66.3/72.1	60/51	33.7/27.9	1.32 (0.84–2.06)	1.34 (0.85–2.10)
≥65	133/141	79/119	59.4/84.4	54/22	40.6/15.6	3.69 (2.09–6.54)	3.58 (2.00–6.38)
Sex
Male	207/217	137/172	66.2/79.3	70/45	33.8/20.7	1.95 (1.26–3.02)	1.94 (1.25–3.02)
Female	104/107	60/79	57.7/73.8	44/28	42.3/26.2	2.07 (1.16–3.70)	2.21 (1.20–4.05)
Smoking status
Never	179/210	106/164	59.2/78.1	73/64	40.8/21.9	2.45 (1.58–3.82)	2.48 (1.58–3.89)
Regular	132/114	91/87	68.9/76.3	41/27	31.1/23.7	1.45 (0.82–2.56)	1.44 (0.81–2.54)
Alcohol use
Never	216/220	129/175	59.7/79.5	87/45	40.3/20.5	2.62 (1.71–4.01)	2.61 (1.70–3.99)
Regular	95/104	68/76	71.6/73.1	27/28	28.4/26.9	1.08 (0.58–2.01)	1.16 (0.60–2.25)

^† Odds ratios were obtained from a logistic regression model with adjustment for age, sex, smoking status, and alcohol use.