Table 4.

 Adverse events following preoperative chemotherapy

	Paclitaxel (n = 29)			FEC100 (n = 56)
	Any grade	Grade 3	Grade 4	Any grade	Grade 3	Grade 4
	n (%)	n (%)	n (%)	n (%)	n (%)	n (%)
Anorexia	6 (21)	0	0	25 (45)	1 (2)	0
Fatigue	22 (76)	1 (3)	1 (3)	44 (79)	2 (4)	0
Nausea	7 (24)	0	0	36 (64)	0	0
Vomiting	2 (7)	0	0	23 (41)	4 (7)	0
Diarrhea	11 (38)	0	0	13 (23)	3 (5)	0
Constipation	15 (52)	0	0	31 (55)	1 (2)	0
Mucositis	0 (0)	0	0	13 (23)	1 (2)	0
Dysgeusia	2 (7)	0	0	4 (7)	0	0
Peripheral neuropathy	26 (90)	1 (3)	0	16 (29)	0	0
Alopecia	29 (100)	NA	NA	56 (100)	NA	NA
Hand‐foot syndrome	0 (0)	0	0	2 (4)	0	0
Rash	3 (10)	0	0	1 (2)	0	0
Allergic reaction	1 (3)	0	0	0	0	0
Itching	1 (3)	0	0	0	0	0
Phlebitis	0 (0)	0	0	1 (2)	0	0
Myalgia	2 (7)	0	0	0	0	0
Infection	2 (7)	0	0	13 (23)	5 (9)	2 (4)
Febrile neutropenia	0 (0)	0	0	7 (13)	2 (4)	0
Leukopenia	19 (65)	1 (3)	0	53 (95)	28 (50)	15 (27)
Neutropenia	14 (48)	3 (10)	0	53 (95)	2 (4)	49 (88)
Anemia	15 (52)	0	0	37 (66)	2 (4)	0
Thrombocytopenia	0 (0)	0	0	3 (5)	1 (2)	0
AST elevation	15 (52)	0	0	23 (41)	0	0
ALT elevation	13 (45)	1 (3)	0	22 (39)	0	0
Total bilirubin elevation	3 (10)	0	0	3 (5)	0	0
Creatinine elevation	1 (3)	0	0	1 (2)	0	0
Hyperglycemia	3 (10)	0	0	14 (25)	0	0
All events	212 (27.0)	7 (0.9)	1 (0.1)	494 (32)	52 (3.6)	66 (4.5)

ALT, alanine transaminase; AST, aspartate transaminase; NA, not applicable.