Figure 4.
Effect of SGN‐30 and SGN‐35 on growth of HTLV‐I‐infected cells in NOD/SCID mice. Seven‐week‐old female mice were subcutaneously engrafted with HUT‐102 or Karpas 299 cells (1 × 107 and 2 × 107 cells, respectively). One day after injection of cells, mice received i.p. SGN‐30 (2 mg/kg) (a,b) or SGN‐35 (1 mg/kg) (c) diluted in 200 μL PBS every 3 days for a total of five injections. The tumor size was measured at 11, 14 and 17 days. Data shown represent mean value ± SD for four mice of each group obtained from a representative experiment in two independent experiments. Statistically significant differences between mAb‐treated and control mice are shown (**P < 0.01).