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. 2005 May 19;96(5):303–307. doi: 10.1111/j.1349-7006.2005.00049.x

Figure 1.

Figure 1

Effect of combination treatment with DC therapy and intratumoral IL‐12 gene delivery against a B16F10 subcutaneous tumor. (a) Growth of injected tumors in the right flank was inhibited significantly with IL‐12 gene therapy alone, DC therapy alone and DC therapy plus IL‐12 gene therapy in comparison to injection of PBS (P < 0.001). (b) Growth of the non‐injected tumors on the contralateral side was inhibited significantly with IL‐12 gene therapy alone and DC therapy alone in comparison to that with PBS (P < 0.05). The growth was inhibited significantly with DC therapy plus IL‐12 gene therapy in comparison to that with IL‐12 gene therapy alone and DC therapy alone (P < 0.05). The growth inhibition was greater in the mice given DC therapy plus IL‐12 gene therapy than in those injected with PBS (P < 0.001). Each group comprised eight mice. Data are presented as mean ± SE. *P < 0.05, **P < 0.001.