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Incidences (%) of proliferative lesions in the livers of rats treated with Alz or Rub in a medium‐term multi‐organ carcinogenesis bioassay
| Lesion | Control | Alz | Rub | ||
|---|---|---|---|---|---|
| 0.008% | 0.04% | 0.008% | 0.04% | ||
| n† | 11 | 18 | 17 | 21 | 20 |
| Nodular hepatocellular hyperplasia | 0 | 0 | 0 | 0 | 10 |
| Altered hepatocellular focus | 100 | 100 | 100 | 100 | 100 |
| Hepatocellular adenoma | 0 | 0 | 0 | 4.8 | 5 |
| Hemangiosarcoma | 0 | 0 | 0 | 4.8 | 0 |
| Cholangiocellular hyperplasia | 9.1 | 11.1 | 0 | 0 | 0 |
†Effective number of animals. Alz, alizarin; Rub, rubiadin.
