Disease‐specific Kaplan–Meier survival curves with respect to the mutational status for the three genes (EGFR/p53/K‐ras) in p‐stage I (a) and p‐stages II–IV cases (b), and for two genes (EGFR/p53) in all p‐stages for the hobnail cell type (c). The + or − indicate cases with or without mutations, respectively. Numbers in parentheses show numbers of patients. (a) The 5‐year survival rate for −/+/+ was significantly lower than those for −/−/−, −/+/−, +/−/−, and +/+/−, respectively (P < 0.01, <0.01, <0.01, and <0.05) in p‐stage I. (b) In contrast, there were no significant differences between any combinations in p‐stages II–IV cases. (c) The survival rate for +/− was significantly higher than that of −/+ with the hobnail cell type (P < 0.05).