Table 4.
p53 mutational spectra and smoking status for subtypes by cell type and WHO classifications
| Subtypes | No. of cases | No. of p53 mutations (%) | Smoking status | ||||
|---|---|---|---|---|---|---|---|
| All mutations | Point mutation | Deletion/insertion | No. of smokers (%) | ||||
| CpG to CpA transition | G to T transversion | Others | |||||
| All cases | 223 | 100 (45) | 22 (22) | 26 (26) | 29 (29) | 23 (23) | 125 (56) |
| Cell type classification | |||||||
| Hobnail type | 102 | 30 (29) | 14 (47) | 6 (20)‡*** | 5 (17) | 5 (17)†** | 42 (41) |
| Mixed cell type | 49 | 20 (41) | 1 (5)○* | 2 (10)‡** | 8 (40)○*** | 9 (45) | 24 (49) |
| Columnar/cuboidal cell type | 44 | 33 (75) | 4 (12)○* | 13 (39) | 9 (27) | 7 (21) | 38 (86)○*†* |
| Polygonal/oval cell type | 19 | 12 (63) | 3 (25) | 3 (25) | 5 (42)○*** | 1 (8)†** | 16 (84)○*†* |
| Goblet type | 7 | 3 (43) | 0 | 0 | 2 (67) | 1 (33) | 4 (57)‡ |
| Unclassified | 2 | 2 | 0 | 2 | 0 | 0 | 1 (50) |
| WHO classification | |||||||
| Acinar | 33 | 24 (73) | 4 (17) | 8 (33) | 7 (29) | 5 (21) | 29 (88) |
| Papillary | 27 | 11 (41) | 3 (27) | 5 (45)¶*** | 1 (9) | 2 (18) | 18 (67)§**¶*** |
| Bronchioloalveolar carcinoma | 2 | 1 (50) | 0 | 0 | 1 (100) | 0 | 0§**#*** |
| Solid adenocarcinoma with mucin | 10 | 7 (70) | 2 (29) | 2 (29) | 3 (43) | 0 | 8 (80) |
| Adenocarcinoma with mixed subtypes | 149 | 57 (38) | 13 (23) | 11 (19) | 17 (30) | 16 (28) | 70 (47)§*#** |
| Unclassified | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
○ vs hobnail cell type; †vs mixed cell type; ‡vs columnar/cuboidal cell type; §vs acinar; #vs solid adenocarcinoma with mucin; ¶vs adenocarcinoma with mixed subtypes. The number of symbols *, **, ***, express P‐values; *P < 0.01, **P < 0.05, ***P < 0.1, respectively, by chi‐squared test or Fisher’s exact test. WHO, World Health Organization.