Figure 4.
Mutagenic activities of various carcinogens in the Salmonella typhimurium tester strains TA100 (upper, six NOC) and TA98 (lower, four HCA, BP and AFB1) in the presence of liver S9 from rats treated with NMBA, curcumin or both. Each test was carried out in duplicate (four to eight plates) with liver S9 pooled from five rats each treated with vehicle (Group 1; clear), NMBA (Group 2; light stippled), 0.05% curcumin (Group 3; hatched), 0.2% curcumin (Group 4; horizontal) or NMBA + 0.2% curcumin (Group 6; solid) for up to 6 weeks. Each bar represents the means ± SD after subtraction of spontaneous revertants (TA100, 108–136; TA98, 9–14). DMN and DEN were assayed in both doses of 1 and *10 mg/plate, and Trp‐P‐2 was in 0.3 µg/plate.