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. 2009 Jun 23;100(10):1779–1785. doi: 10.1111/j.1349-7006.2009.01258.x

Figure 3.

Figure 3

Schematic presentation of the canonical Wnt signaling and cyclooxygenase (COX)‐2/prostaglandin PGE2 pathway in gastric tumor development. β‐Catenin mutations, SFRPs methylation, and downregulation of E‐cadherin or β‐TrCP can activate Wnt signaling in gastric cancer. Cooperation of the Helicobacter pylori (H. pylori)‐induced COX‐2/PGE2 pathway with Wnt activation leads to the development of gastric adenocarcinoma. Without the induction of the PGE2 pathway, Wnt activation alone does not cause gastric cancer development. mPGES‐1, microsomal PGE synthase‐1.