Table 4.
Cox’s proportional hazards model analysis of prognostic factors in patients with colorectal cancer
| Variables | Hazards ratio | 95% CI | Unfavorable/favorable | P‐value |
|---|---|---|---|---|
| Univariate analysis | ||||
| EZH2 | 0.391 | 0.185–0.827 | Positive/negative | 0.014* |
| Age(years) | 0.958 | 0.409–1.157 | ≥65/<65 | 0.158 |
| Gender | 1.022 | 0.611–1.710 | Male/female | 0.934 |
| Serum CEA level | 3.862 | 2.294–6.500 | 5.0>/5.0≤ | <0.001* |
| Serum CA19‐9 level | 2.534 | 1.495–4.293 | 37>/37≤ | 0.001* |
| pT factor | 4.517 | 1.102–18.516 | T1≥/T2≤ | 0.036* |
| pN factor | 2.450 | 1.441–4.167 | N−/N+ | 0.001* |
| M factor | 8.570 | 4.986–14.731 | M0/M1 | <0.001* |
| Multivariate analysis | ||||
| EZH2 | 0.423 | 0.185–0.967 | Positive/negative | 0.041* |
| Age(years) | 0.958 | 0.548–1.675 | ≥65/<65 | 0.881 |
| Gender | 1.196 | 0.688–2.078 | Male/female | 0.526 |
| Serum CEA level | 1.445 | 0.731–2.858 | 5.0>/5.0≤ | 0.29 |
| Serum CA19‐9 level | 1.169 | 0.604–2.262 | 37>/37≤ | 0.643 |
| pT factor | 2.089 | 0.483–9.031 | T1≥/T2≤ | 0.324 |
| pN factor | 1.447 | 0.783–2.673 | N−/N+ | 0.238 |
| M factor | 4.620 | 2.380–8.969 | M0/M1 | <0.001* |
*P < 0.05 (Fisher’s exact test). CEA, carcinoembryonic antigen; CI, confidence interval.