Table 1.

Effects of Drh1 on preneoplastic liver lesion induced by 3′‐Me‐DAB

Phenotype parameters	F344	DRH.F344‐Drh1	DRH
No. of EAF per a 40X filed	9.6 ± 2.7*, †	8.6 ± 1.4 †	2.5 ± 0.8
Percent GST‐P positive area	44.2 ± 5.2	12.6 ± 2.8	3.0 ± 1.6
Mean area of EAF (mm2)	0.08 ± 0.02	0.02 ± 0.006	0.007 ± 0.004
GST‐P mRNA (fold)	36.1 ± 10.5	12.2 ± 2.7	2.2 ± 0.51
Percent CyclinD1 positive cells	29.1 ± 7.3	17.1 ± 3.1	7.1 ± 2.5
Percent PCNA positive cells	23.1 ± 4.4	10.6 ± 4.2	3.7 ± 0.9
Percent area of fibrosis	17.9 ± 3.3	11.3 ± 2.9	5.7 ± 0.8
Percent TUNEL positive cells	1.3 ± 0.8 ‡	2.9 ± 1.5 ‡	57.9 ± 7.3

^* Mean ± SD, n = 6. Significantly different in ANOVA (< P, 0.05) except for

^† (P = 0.23) and

^‡ (P = 0.64).