Table 1.

Expression of Pla2g2a prevents tumorigenesis in Muc2^−/– mice

Genotype	Sex	N	Large intestine tumor multiplicity	Large intestine tumor incidence	Duodenum tumor multiplicity	Duodenum tumor incidence	Ileum tumor multiplicity	Ileum tumor incidence
Muc2−/–	M
Combined		29	3.6 ± 2.9	90%	0.9 ± 1.2	45%	2.3 ± 3.4	55%
30 weeks		15	2.6 ± 1.8	87%	0.3 ± 0.6	20%	2.5 ± 3.5	60%
60 weeks		14	5.4 ± 3.1	100%	1.6 ± 1.1	70%	1.9 ± 3.4	50%
Muc2−/– Pla2+	M
Combined		18	0.4 ± 0.6	33%	0.5 ± 0.5	33%	0.2 ± 1.2	5%
30 weeks		10	0.3 ± 0.4*	30%	0.3 ± 0.5	30%	0	0
60 weeks		8	0.5 ± 0.8**	38%	0.8 ± 1.0***	38%	0.5 ± 1.7	13%
Muc2−/–	F
Combined		21	1.5 ± 1.7	62%	0.3 ± 0.6	19%	1.8 ± 2.3	52%
30 weeks		8	2.6 ± 1.6	100%	0.4 ± 1.7	25%	0.9 ± 2.8	25%
60 weeks		13	0.8 ± 1.4	33%	0.2 ± 0.7	15%	2.3 ± 2.3	70%
Muc2−/– Pla2+	F
Combined		21	0.1 ± 0.6	5%	0	0	1.2 ± 2.3	33%
30 weeks		14	0.2 ± 0.8	7%	0	0	0.3 ± 0.6	21%
60 weeks		7	0		0	0	3.0 ± 1.5	57%

^* P = 0.03;

^** P = 0.0001;

^*** P = 0.21.

P‐values compare age and sex matched classes. N = number of mice.