Table 2.
Dose‐limiting and other grade 3/4 toxicity observed during bendamustine treatment
| Dose level | DLT criteria | No. of cases | Other grade 3/4 toxicities (non–dose limiting) |
|---|---|---|---|
| 90 mg/m2 | Grade 4 neutropenia† | 0 | Lymphocytopenia: 1 grade 4, 2 grade 3 Neutropenia: 1 grade 3 Leukopenia: 1 grade 3 |
| Platelets <10 000/mm3‡ | 0 | ||
| Other grade 4 hematologic toxicity§ | 0 | ||
| Grade ≥3 non‐hematologic toxicity | 0 | ||
| 120 mg/m2 | Grade 4 neutropenia† | 0 | Lymphocytopenia: 3 each grades 3 and 4 Neutropenia: 1 each grades 3 and 4 Leukopenia: 3 grade 3 |
| Platelets <10 000/mm3‡ | 0 | ||
| Other grade 4 hematologic toxicity§ | 0 | ||
| Grade ≥3 non‐hematologic toxicity | 0 |
†Grade 4 neutropenia lasting >1 week and accompanied by fever (38°C or higher). ‡Grade 4 thrombocytopenia or hemorrhage requiring platelet transfusion. §Any other grade 4 hematological toxicity excluding lymphopenia and differential white blood cell count (%).